PAPERS
Evaluation of DNA minicircles for delivery of adenine and cytosine base editors using activatable gene on “GO” reporter imaging systems
This study introduces non-viral minicircles for delivering CRISPR base editors, for their improved safety compared to viral methods. Using enhanced bioluminescence and GFP activatable reporter gene systems, minicircles were shown as delivery vehicles for base editors.
Here you can find a list of the Ronald Lab Manuscripts.
Ronald Lab Manuscript
Evans MM*, Liu S*, Krautner JS, Seguin CG, Leung R, Ronald JA. Evaluation of DNA minicircles for delivery of adenine and cytosine base editors using activatable gene on “GO” reporter imaging systems. Molecular Therapy - Nucleic Acids. 2024 Sep; PMID: 102248. *co-first author
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Shalaby N, Xia Y, Kelly JJ, Sanchez-Pupo R, Martinez F, Fox MS, Thiessen JD, Hicks JW, Scholl TJ, Ronald JA. Imaging CAR-NK cells targeted to HER2 ovarian cancer with human sodium-iodide symporter-based positron emission tomography. Eur J Nucl Med Mol Imaging. Germany; 2024 May 9; PMID: 38722382
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Fu Y, Wang T, Ronald JA. A synthetic notch (synNotch) system linking intratumoral immune-cancer cell communication to a synthetic blood biomarker assay. Front Pharmacol. Switzerland; 2023 Dec7; PMCID: PMC10740178
McRae SW, Cleary M, DeRoche D, Martinez FM, Xia Y, Caravan P, Gale EM, Ronald JA, Scholl TJ. Development of a Suite of Gadolinium-Free OATP1-Targeted Paramagnetic Probes for Liver MRI. J Med Chem. United States; 2023 May 25;66(10):6567–6576. PMID: 37159947
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Wang T, Chen Y, Nystrom NN, Liu S, Fu Y, Martinez FM, Scholl TJ, Ronald JA. Visualizing cell-cell communication using synthetic notch activated MRI. Proc Natl Acad Sci U S A. United States; 2023 Mar 14;120(11):e2216901120. PMCID: PMC10089199
Nyström NN, McRae SW, Martinez FM, Kelly JJ, Scholl TJ, Ronald JA. A Genetically Encoded Magnetic Resonance Imaging Reporter Enables Sensitive Detection and Tracking of Spontaneous Metastases in Deep Tissues. Cancer Res. United States; 2023 Mar 2;83(5):673–685. PMID: 36512633
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Shalaby N, Kelly JJ, Sehl OC, Gevaert JJ, Fox MS, Qi Q, Foster PJ, Thiessen JD, Hicks JW, Scholl TJ, Ronald JA. Complementary early-phase magnetic particle imaging and late-phase positron emission tomography reporter imaging of mesenchymal stem cells in vivo. Nanoscale. England; 2023 Feb 16;15(7):3408–3418. PMID: 36722918
Williams RJ, Sehl OC, Gevaert JJ, Liu S, Kelly JJ, Foster PJ, Ronald JA. Dual Magnetic Particle Imaging and Akaluc Bioluminescence Imaging for Tracking Cancer Cell Metastasis. Tomography. Switzerland; 2023 Jan 25;9(1):178–194. PMCID: PMC9968184
Fu Y, Wang T, Ronald JA. A synthetic notch (synNotch) system linking intratumoral immune-cancer cell communication to a synthetic blood biomarker assay. Front Pharmacol. Switzerland; 2023;14:1304194. PMCID: PMC10740178
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Nyström NN, Liu H, Martinez FM, Zhang XA, Scholl TJ, Ronald JA. Gadolinium-free Magnetic Resonance Imaging of the Liver via an Oatp1-Targeted Manganese(III) Porphyrin. J Med Chem. United States; 2022 Jul 19; PMID: 35852350
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Shalaby N, Kelly J, Martinez F, Fox M, Qi Q, Thiessen J, Hicks J, Scholl TJ, Ronald JA. A Human-derived Dual MRI/PET Reporter Gene System with High Translational Potential for Cell Tracking. Mol Imaging Biol. United States; 2022 Apr;24(2):341–351. PMCID: PMC9235057
Dubois VP, Sehl OC, Foster PJ, Ronald JA. Visualizing CAR-T cell Immunotherapy Using 3 Tesla Fluorine-19 MRI. Mol Imaging Biol. United States; 2022 Apr;24(2):298–308. PMCID: PMC8983548
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Liu S, Nyström NN, Kelly JJ, Hamilton AM, Fu Y, Ronald JA. Molecular Imaging Reveals a High Degree of Cross-Seeding of Spontaneous Metastases in a Novel Mouse Model of Synchronous Bilateral Breast Cancer. Mol Imaging Biol. United States; 2022 Feb;24(1):104–114. PMCID: PMC8760205
Liu S, Su Y, Lin MZ, Ronald JA. Brightening up Biology: Advances in Luciferase Systems for in Vivo Imaging. ACS Chem Biol. United States; 2021 Dec 17;16(12):2707–2718. PMCID: PMC8689642
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Parkins KM, Melo KP, Chen Y, Ronald JA, Foster PJ. Visualizing tumour self-homing with magnetic particle imaging. Nanoscale. England; 2021 Mar 28;13(12):6016–6023. PMID: 33683241
Wang T, Chen Y, Goodale D, Allan AL, Ronald JA. A survivin-driven, tumor-activatable minicircle system for prostate cancer theranostics. Mol Ther Oncolytics. United States; 2021 Mar 26;20:209–219. PMCID: PMC7889447
Kelly JJ, Saee-Marand M, Nyström NN, Evans MM, Chen Y, Martinez FM, Hamilton AM, Ronald JA. Safe harbor-targeted CRISPR-Cas9 homology-independent targeted integration for multimodality reporter gene-based cell tracking. Sci Adv. United States; 2021 Jan;7(4). PMCID: PMC7817109
Parkins KM, Dubois VP, Kelly JJ, Chen Y, Knier NN, Foster PJ, Ronald JA. Engineering Circulating Tumor Cells as Novel Cancer Theranostics. Theranostics. Australia; 2020;10(17):7925–7937. PMCID: PMC7359075
Nyström NN, Yip LCM, Carson JJL, Scholl TJ, Ronald JA. Development of a Human Photoacoustic Imaging Reporter Gene Using the Clinical Dye Indocyanine Green. Radiol Imaging Cancer. United States; 2019 Nov;1(2):e190035. PMCID: PMC7983684
Wang T, Chen Y, Ronald JA. A novel approach for assessment of prostate cancer aggressiveness using survivin-driven tumour-activatable minicircles. Gene Ther. England; 2019 May;26(5):177–186. PMID: 30867586
Nyström NN, Hamilton AM, Xia W, Liu S, Scholl TJ, Ronald JA. Longitudinal Visualization of Viable Cancer Cell Intratumoral Distribution in Mouse Models Using Oatp1a1-Enhanced Magnetic Resonance Imaging. Invest Radiol. United States; 2019 May;54(5):302–311. PMID: 30672844
Parkins KM, Hamilton AM, Dubois VP, Wong SM, Foster PJ, Ronald JA. Cellular MRI Reveals Altered Brain Arrest of Genetically Engineered Metastatic Breast Cancer Cells. Contrast Media Mol Imaging. England; 2019;2019:6501231. PMCID: PMC6348811
Chen Y, Wang T, Rogers KA, Rutt BK, Ronald JA. Close Association of Myeloperoxidase-Producing Activated Microglia with Amyloid Plaques in Hypercholesterolemic Rabbits. J Alzheimers Dis. Netherlands; 2019;67(4):1221–1234. PMID: 30689571
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Dubois VP*, Zotova D*, Parkins KM, Swick C, Hamilton AM, Kelly JJ, Ronald JA. Safe Harbor Targeted CRISPR-Cas9 Tools for Molecular-Genetic Imaging of Cells in Living Subjects. CRISPR J. United States; 2018 Dec;1:440–449. PMID: 31021241
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Hamilton AM, Foster PJ, Ronald JA. Evaluating Nonintegrating Lentiviruses as Safe Vectors for Noninvasive Reporter-Based Molecular Imaging of Multipotent Mesenchymal Stem Cells. Hum Gene Ther. United States; 2018 Oct;29(10):1213–1225. PMID: 30101620
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Parkins KM, Dubois VP, Hamilton AM, Makela AV, Ronald JA, Foster PJ. Multimodality cellular and molecular imaging of concomitant tumour enhancement in a syngeneic mouse model of breast cancer metastasis. Sci Rep. England; 2018 Jun 12;8(1):8930. PMCID: PMC5997674
Le TNT, Lim H, Hamilton AM, Parkins KM, Chen Y, Scholl TJ, Ronald JA. Characterization of an Orthotopic Rat Model of Glioblastoma Using Multiparametric Magnetic Resonance Imaging and Bioluminescence Imaging. Tomography. Switzerland; 2018 Jun;4(2):55–65. PMCID: PMC6127346
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Chen Y, Lim P, Rogers KA, Rutt BK, Ronald JA. In Vivo MRI of Amyloid Plaques in a Cholesterol-Fed Rabbit Model of Alzheimer’s Disease. J Alzheimers Dis. Netherlands; 2018;64(3):911–923. PMID: 29966200
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Parkins KM, Hamilton AM, Makela AV, Chen Y, Foster PJ, Ronald JA. A multimodality imaging model to track viable breast cancer cells from single arrest to metastasis in the mouse brain. Sci Rep. England; 2016 Oct 21;6:35889. PMCID: PMC5073295
Manuscript Pre-prints
Pre-prints:
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